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pFLEX

pFLEX is a Python toolkit for evaluating CRISPR screen and co-essentiality networks against biological functional standards such as CORUM-derived modules, Gene Ontology Biological Processes, and pathways.

Use pFLEX to:

  • load one or more gene-by-sample matrices
  • rank gene pairs by correlation or a precomputed score
  • evaluate global precision-recall performance
  • evaluate performance at the functional-standard term level
  • plot benchmark summaries and export result tables